CLOSE

Specials

I agree We use cookies on this website to enhance your user experience. By clicking any link on this page you are giving your consent for us to set cookies. More info

Skip to: Curated Story Group 1
lifesciencesreview
US
EUROPE
APAC
LATAM
  • Home
  • Contributors
  • News
  • Conferences
  • Newsletter
  • Whitepapers
  • Magazine
  • About
×
#

Life Science Review Weekly Brief

Be first to read the latest tech news, Industry Leader's Insights, and CIO interviews of medium and large enterprises exclusively from Life Science Review

Subscribe

loading

Thank you for Subscribing to Life Science Review Weekly Brief

  • Home
  • Contributers

Recommended Insights

How COVID-19 will Accelerate Digital...

Jakirul Islam, Senior Vice President, Bank Asia

Sterile Processing Professional: 30 Years...

Jackie Mallatt, CRCST, Sterile Processing...

Packaging, A Key Element In Improving...

Bertrand Havrileck, Head of Corporate Pharma R&D,...

Top Biotech Developments to Watch for

Jeremy Williams, Life Science Review

What Role Does Digital Technology Play in...

Jeremy Williams, Life Science Review

Managing Risk and Minimizing the...

Timothy Korwan, Director, New Product Development...

In Personalized Medicine Logistics,...

Scott Ohanesian, Senior VP Commercial Operations,...

Unlock the Power of Data

Jijo James, M.D., M.P.H., Chief Medical Officer,...

How COVID-19 will Accelerate Digital...

Jakirul Islam, Senior Vice President, Bank Asia

Sterile Processing Professional: 30 Years...

Jackie Mallatt, CRCST, Sterile Processing...

Packaging, A Key Element In Improving...

Bertrand Havrileck, Head of Corporate Pharma R&D,...

Top Biotech Developments to Watch for

Jeremy Williams, Life Science Review

What Role Does Digital Technology Play in...

Jeremy Williams, Life Science Review

Managing Risk and Minimizing the...

Timothy Korwan, Director, New Product Development...

In Personalized Medicine Logistics,...

Scott Ohanesian, Senior VP Commercial Operations,...

Unlock the Power of Data

Jijo James, M.D., M.P.H., Chief Medical Officer,...

Recent Trend and Development in Pharmaceutical Industry

Richard Hu, Associate Director CMC, Curis
Tweet

In our exciting and ever-changing industry, pharmaceutical and biotech companies must continue innovating not only their technologies but also the way they do business. Let’s review the top three trends that are “hot” in the eyes of a formulation scientist.


The first thing that came to mind is the advancement of CRISPR/Cas9, a gene editing technology developed by Professor Zhang at MIT. Inspired by how living cells disable invading viruses, CRISPR (Clustered Regularly Short Palindromic Repeats) technology utilizes Cas9, a nuclease enzyme, to cut DNA strands at a precise location when the target gene is complexed with a guide-RNA. As a result, scientists can disable certain sequence in that gene and understand the function of that particular sequence. Sequentially, CRISPR also enables scientists to add a desired function to the gene by inserting a pre-fabricated sequence. We all know that genes define who we are as life-forms and individuals. There is no doubt that our genes have a profound effect on our health. While still in its infancy, gene editing certainly has the potential to completely transform not only our industry but our world as well. If something can finally bankrupt our social security, I think gene editing will be it.


For cancer patients, chemotherapy and radiation therapy have long been the only options. Recent development of immuno-oncology has changed the game. In this new hope, scientists are developing drugs that can stimulate our own immune system to recognize and fight cancerous cells. One such advancement is the chimeric antigen receptor (CAR) T-cell technology, in which a patient’s own immune cells are removed, engineered to have the ability to recognize and attack cancerous cells, then infused back to his/her body to fight cancer.


While only approved to treat limited types of cancer and may have severe side effects, the approval of Kymriah® and Yescarta® clearly represents the future of personalized medicine.


Another trend worth mentioning in immunotherapy is the advancement of checkpoint inhibitor. These drugs are often highly targeted, highly efficient and have relatively low side effects. In recent years, antibody-based checkpoint inhibitors have dramatically improved the management of cancer. To me, developing small molecule version of such inhibitors, which are orally available and going to be much cheaper, is even more exciting.


For cancer patients, chemotherapy and radiation therapy have long been the only options. Recent development of immuno-oncology has changed the game


In the foreseeable future, biopharmaceutical companies, regardless of their sizes, will continue to utilize R&D outsourcing to access innovations and expertise. According to Visiongain, the global drug discovery outsourcing market is expected to exceed $40 billion by 2026. Meanwhile, the tide of outsourcing model is certainly shifting, especially at early stage. R&D work is coming back to the States, while some companies start to run clinical trials in developing countries, often-times looking for treatment-naïve patients. I also sense a strong focus from pharmaceutical companies on partnering with academia. In the past few years, several major pharma companies moved their R&D headquarters into the most congested neighbourhoods in Boston, with the intention to put their folks into the proximity of Harvard and MIT. But for God’s sake, put them in the suburb and take a subway to the “Inspiration” when needed. Haven’t they checked out the Boston morning traffic in last twenty years?


Weekly Brief

loading
Towards a New World Order
> <
  • DNA Sequencing 2022

    Top Vendors

    Current Issue
  • BioTech Startups 2022

    Top Vendors

    Current Issue
  • DNA Sequencing 2022

    Top Vendors

    Current Issue
  • BioTech Startups 2022

    Top Vendors

    Current Issue

Read Also

Challenges To Clinical System In China

Cheryl Chen, Director of Clinical Operations, BeiGene
Challenges To Clinical System In China

On Accelerating Bioanalytical Workflow Automation

Ming Li, Director, Bioanalytical and Biomarker Outsourcing Operations, Alexion Pharmaceuticals
On Accelerating Bioanalytical Workflow Automation

Artificial Intelligence and the Healthcare Industry

Kelly H. Zou, PhD, PStat®, FASA, Head of Global Medical Analytics and Real World Evidence, Viatris
Artificial Intelligence and the Healthcare Industry

Cell and Gene therapy - Navigating the next frontier in biomanufacturing

Narayana Rao, Vice President of Biopharma, Asia Pacific Middle-East Africa, Avantor
Cell and Gene therapy - Navigating the next frontier in biomanufacturing
Improvements in Insulin Delivery Over Time and Expectations for the Future

Improvements in Insulin Delivery Over Time and Expectations for the Future

Jesper Lekdorf, MD, Sr Medical Director, Head of Medical Affairs, Novo Nordisk Japan
Machine Learning in the Life Sciences

Machine Learning in the Life Sciences

Eric Staib, Vice President, Compliance & Quality Management, Signant Health

Harnessing Big Data to Accelerate Clinical Trial Recruitment

Leigh Householder, Executive Vice President, Omnichannel Strategy; Claire Riches, Senior Vice President, Global Solutions; and Brooke Belk, Vice President, Program Strategy, Syneos Health
Harnessing Big Data to Accelerate Clinical Trial Recruitment

How Will Digital Transformation Revolutionize The Pharma Sector In The Light Of The Covid-19 Pandemic?

Robert Peterson, Head Of Sales Health and Life Sciences Americas and Asia, BT - Health and Life Sciences
How Will Digital Transformation Revolutionize The Pharma Sector In The Light Of The Covid-19 Pandemic?
Loading...

Copyright © 2022 Life Science Review . All rights reserved. |  Subscribe |  About Us follow on linkedin

This content is copyright protected

However, if you would like to share the information in this article, you may use the link below:

https://www.lifesciencesreview.com/cxoinsight/recent-trend-and-development-in-pharmaceutical-industry-nwid-32.html