PermeGear
Driving Innovations in Membrane Permeation Testing

Navigating the specialized field of permeation and release testing in the bioprocessing sector, PermeGear emerges as a pivotal player providing distinctive solutions. Its solutions are designed to address the nuanced needs of researchers, cannabis and cosmetic product manufacturers and agricultural scientists. Shifting the traditional focus from broad pharmaceutical challenges, the company zeroes in on the precision testing of drugs through diverse membranes, including human and animal skin, as well as synthetic alternatives.

Central to PermeGear’s expertise is its array of customized Franz, In-Line and Side-Bi-Side cells developed for intricate tasks. These instruments, along with its advanced automated systems, revolutionize the standard approach in drug development, ensuring rigorous and accurate permeation testing tailored to the requirements of each project.

Focused on helping customers test topical and transdermal products, PermeGear’s Franz cells allow the testing of a wide variety of products, including creams, gels, ointments, foams, lotions and cosmetics. This enables producers to back up claims about product performance, provide the FDA with data on product performance and demonstrate that their generic product is equivalent to a name-brand product.

PermeGear’s Side-Bi-Side cells are a more specialized product often used to test the diffusion coefficient of membranes and other semi-permeable materials. The company is one of the few remaining organizations that specializes in providing custom diffusion cells to meet customer needs.

A leader in bioprocessing, PermeGear addresses the FDA’s increasing demands for detailed drug testing and meets the challenges of In Vitro Permeation Testing (IVPT) and automation.Its solutions not only comply with rigorous FDA standards but streamline essential processes, distinguishing it in the pharmaceutical industry.

Traditionally, permeation testing is a long, cumbersome process involving labor-intensive sampling procedures that take a minimum of eight hours and can stretch up to 72 hours.

“Scientists often have to come in at 3 a.m. for manual sampling—a task no one truly desires. There is a clear need for automated solutions for permeation testing, and PermeGear is working on special cells that can be automated,” says Marty Hansen, director of sales.

With a focus on innovation, PermeGear is addressing this challenge by developing a new cell type to tackle bubble formation during sample extraction, which currently impedes automation. This solution is poised to revolutionize the process, introducing an auto-sampler for complete automation of permeation testing and enhancing efficiency and precision for pharmaceutical companies. With nearly 100 years of collective experience among its leading experts, PermeGear is more than just a solution provider; it’s a think tank of specialists who have been consulted multiple times by various stakeholders, including the FDA, to serve on committees for setting research criteria. It has designed over 1,000 custom cells, tailoring each to meet the individual requirements of clients, something many other competitors in the market are reluctant to offer.

The team’s impact is evident across numerous success stories, including individuals who attracted major pharmaceutical companies with PermeGear’s specialized equipment. The company’s commitment doesn’t end with the sale. Its post-sale services go above and beyond standard industry warranties. If something can be fixed, regardless of how long it has been since the purchase, PermeGear offers free replacements, highlighting its ultimate goal of making customers happy.

PermeGear not only provides innovative solutions but also offers invaluable information through its robust, searchable database of research and white papers, boasting tens of thousands of downloads and inviting many contributions from scientists. This extensive library is a vital resource for pharmaceutical professionals, enabling them to contribute to and benefit from this treasure trove of data.

With its highly customizable solutions, relentless focus on innovation, and a vast reservoir of freely available industry knowledge, PermeGear stands as an unmatched partner for pharmaceutical companies seeking to optimize their permeation testing processes.