Transdermal Delivery in the Age of Biologics: Charting the Future of Drug Absorption

Pharmaceutical innovation is shifting towards patient-centric transdermal drug delivery systems, which enhance comfort and effectiveness while bypassing gastrointestinal limitations, thereby promising improved adherence and therapeutic.

Life Sciences Review | Monday, June 23, 2025

Pharmaceutical innovation is increasingly focused on efficient, patient-centric, and less invasive methods, with Novel Transdermal Drug Delivery Systems emerging as a revolutionary alternative to oral and injectable therapies. These systems, designed with the patient's comfort and convenience in mind, leverage the skin, the body's largest organ, as a gateway for systemic drug absorption, bypassing the gastrointestinal tract and hepatic first-pass metabolism, which often degrade drugs or limit their bioavailability.

Pushing Permeation: Advanced Technologies and Mechanisms

At its core, transdermal drug delivery hinges on the principle of a drug permeating through the skin layers to reach the systemic circulation. The outermost layer of the skin, the stratum corneum, serves as the primary barrier, a formidable challenge for many drug molecules. Novel transdermal systems are ingeniously designed to overcome this barrier, employing various strategies to enhance drug penetration while maintaining skin integrity and patient comfort.

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One of the most significant advancements in recent years has been the evolution of microneedle technology. These microscopic needles, typically ranging from a few to several hundred micrometers in length, create transient micro-channels in the stratum corneum, allowing for the passage of drugs that would otherwise be unable to permeate the skin. Microneedles are designed to be minimally invasive, often causing no pain or discomfort as they do not reach the nerve endings in the deeper skin layers. They can be fabricated from various materials, including silicon, metals, or biodegradable polymers. Dissolving microneedles, for instance, are made from drug-loaded polymers that dissolve within the skin, releasing their therapeutic payload. Hydrogel-forming microneedles, on the other hand, swell upon insertion, facilitating controlled drug release from a hydrogel matrix. The versatility of microneedle arrays enables precise control over drug delivery, making them suitable for a wide range of therapeutics, including large molecules such as peptides, proteins, and vaccines, which traditionally require injectable administration.

Beyond mechanical disruption, other physical enhancement techniques are gaining prominence. Iontophoresis utilizes a low-level electric current to drive charged drug molecules across the skin. This active delivery method is particularly effective for ionized drugs and offers more precise control over the rate of drug delivery compared to passive diffusion. Similarly, electroporation employs short, high-voltage electrical pulses to create temporary pores in the skin, facilitating the transport of larger molecules. Sonophoresis, also known as phonophoresis, utilizes the power of ultrasound waves to temporarily disrupt the lipid bilayers of the stratum corneum, thereby enhancing the permeability of the skin for various therapeutic agents. These active methods offer the potential for on-demand drug delivery and improved bioavailability for a broader range of compounds.

Nanocarriers and Smart System Integration

The advent of nanocarriers has also overhauled the field of transdermal delivery. These microscopic systems, including liposomes, niosomes, and transethosomes, encapsulate drug molecules, improving their solubility, stability, and skin penetration. Liposomes, composed of lipid bilayers, can carry both hydrophilic and lipophilic drugs. Niosomes, formed from non-ionic surfactants, offer similar advantages with enhanced stability. Transethosomes, an advanced vesicular system, utilize ethanol as a permeation enhancer, enabling deeper skin penetration due to their deformable nature. The integration of these nanocarriers with physical enhancement techniques promises synergistic effects, further amplifying drug permeation and therapeutic efficacy.

The innovation in NTDDS extends to the design of the systems themselves. Modern transdermal patches are far more sophisticated than their predecessors, incorporating advanced materials that minimize skin irritation and improve adhesion. The development of specialized patches for specific demographics or conditions is expanding the reach of transdermal therapy to previously underserved areas. The integration of smart technologies is on the horizon, with the potential for sensor-integrated patches that can dynamically adjust drug release based on real-time physiological feedback, thereby achieving truly personalized medicine. The increasing role of artificial intelligence and machine learning in optimizing formulations, predicting skin permeability, and streamlining the development process for new transdermal systems is a testament to the precision and efficiency of NTDDS.

Broadening Impact and Future Trajectory

The advantages offered by novel transdermal drug delivery systems are multifaceted. They provide a non-invasive and patient-friendly alternative to injections and oral medications, significantly improving patient compliance, particularly for long-term therapies. By bypassing the gastrointestinal tract, they eliminate issues related to drug degradation by digestive enzymes and variations in absorption due to food intake. The controlled and sustained release of medication over extended periods, ranging from hours to several days, results in more consistent blood drug levels, thereby avoiding the peaks and troughs associated with conventional dosing and potentially reducing systemic side effects. The ease of discontinuation of medication by simply removing the patch adds another layer of safety and control. Moreover, the visibility of drug administration can enhance adherence and peace of mind for patients and caregivers.

The current trajectory of NTDDS points towards a future where more drugs, including biologics and complex molecules, can be effectively delivered through the skin. This ongoing evolution is driven by the increasing global prevalence of chronic diseases requiring continuous medication, a growing preference for non-invasive treatments, and a sustained focus on improving patient convenience and quality of life. The expansion of research into new permeation enhancers, innovative patch designs, and the convergence of various cutting-edge technologies are collectively pushing the boundaries of what is possible in transdermal drug delivery, solidifying its position as a transformative force in modern healthcare.

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The Expanding Role of Professional Training in Life Sciences

The life sciences industry, encompassing pharmaceuticals, biotechnology, medical devices, and related fields, is an ever-evolving sector at the forefront of human health and well-being. Integral to its continuous advancement is a robust and adaptive ecosystem of training services. These services are crucial for equipping professionals with the specialised knowledge and skills required to navigate complex scientific, technological, and regulatory landscapes. Evolving Modalities and Diverse Curricula At its core, life science training aims to foster a highly skilled workforce, from entry-level technicians to seasoned researchers and executives. This encompasses a broad spectrum of educational offerings, ranging from foundational scientific principles to advanced technical proficiencies and intricate regulatory compliance. Traditional classroom-based instruction remains relevant, particularly for in-depth theoretical understanding and the delivery of structured curricula. However, the industry has seen a significant proliferation and diversification of training modalities, driven by technological advancements and the need for greater accessibility and flexibility. The adaptability of professionals in embracing new training modalities is a testament to their commitment to staying current in the rapidly changing industry. E-learning platforms have emerged as a cornerstone of modern life science training. These platforms offer a wealth of on-demand courses, interactive modules, and virtual simulations, allowing professionals to learn at their own pace and from any location. This flexibility has become even more valuable in the wake of the COVID-19 pandemic, which has accelerated the adoption of remote learning in a globalised industry where continuous professional development is paramount. Live online sessions, often blending expert instruction with interactive elements, also provide a dynamic learning experience, fostering real-time engagement and discussion. Many training providers now offer a hybrid approach, combining the benefits of virtual learning with periodic in-person workshops to provide hands-on experience and facilitate networking. The content of life science training is incredibly diverse, reflecting the multifaceted nature of the industry. Core scientific disciplines such as molecular biology, biochemistry, pharmacology, and genetics form the bedrock of many programs. Beyond these fundamentals, specialised training areas are critical. For instance, in drug discovery and development, training encompasses everything from target identification and lead optimisation to clinical trial design, data management, and pharmacovigilance. Manufacturing and quality assurance are other significant domains, with courses covering Good Manufacturing Practices (GMP), Good Laboratory Practices (GLP), and Quality Management Systems (QMS) to ensure product safety and efficacy. Specialised Knowledge and Complementary Skills Regulatory affairs training is of paramount importance in the life sciences. Given the stringent regulations governing product development, approval, and marketing across different global jurisdictions, professionals require deep expertise in areas such as the FDA, EMA, and other regional guidelines. This includes training on regulatory submissions, post-market surveillance, and adherence to evolving compliance standards. The role of regulatory bodies in shaping the training landscape cannot be overstated, as they drive the need for continuous learning and adaptation to new standards and regulations. The rise of new modalities, such as cell and gene therapies and advanced therapy medicinal products (ATMPs), has further necessitated specialized training in their unique regulatory pathways and manufacturing considerations. Beyond scientific and regulatory knowledge, the modern life science professional requires a blend of complementary skills. Training programs increasingly incorporate modules on data analytics, bioinformatics, and the application of artificial intelligence and machine learning in research, development, and clinical settings. The ability to interpret complex datasets, utilize computational tools for drug discovery, and leverage AI for predictive modeling is becoming essential. However, it's necessary to note that soft skills, such as effective scientific communication, technical writing, project management, and leadership, are equally vital for success in collaborative and interdisciplinary environments. The industry is recognizing the importance of these skills, and training in these areas helps professionals not only excel in their technical roles but also to articulate scientific findings, lead teams, and navigate the commercial aspects of the industry. Practical Application and Future Directions A notable trend in the life science training landscape is the increasing emphasis on practical, skill-based learning. This goes beyond theoretical knowledge to focus on the application of concepts in real-world scenarios. Many programs now offer hands-on laboratory training, virtual lab simulations, and opportunities to work on industry-relevant projects. This practical orientation ensures that graduates and professionals are not only knowledgeable but also proficient in executing tasks and solving problems encountered in their daily work. The value of these practical skills in the industry cannot be overstated, as they provide professionals with the confidence to apply their knowledge effectively. The future trajectory of life science training services is closely intertwined with the ongoing evolution of the broader industry. The accelerating pace of scientific discovery, the increasing complexity of therapeutic modalities, and the pervasive integration of digital technologies are all shaping the demand for specific skill sets. Training providers are continuously adapting their curricula to address emerging areas such as personalized medicine, digital health technologies (e.g., wearables, telemedicine), and advanced manufacturing techniques like 3D printing for medical devices. The focus will likely intensify on interdisciplinary training, bridging the gap between traditional life sciences and advanced computing, engineering, and data science. As the industry moves towards more integrated and patient-centric approaches, training will also emphasize understanding the entire product lifecycle and the broader healthcare ecosystem. ...Read more

Inventus appoints Stacy Hurt and Jon French as Non-Executive Advisers

In their roles, they will support the continued evolution of the company as a technology and patient-first business Inventus, the only company in the world dedicated to creating purpose-bult devices and technology solutions exclusively for clinical trials, has today announced two key appointments. Jon French, Managing Director at Google and Stacy Hurt, Chief Patient Officer at Parexel have been selected to join the Inventus Board as Non-Executive Advisers. Both bring a wealth of experience which will serve to strengthen the focus of Inventus as a technology and patient-first business. French has more than two decades in senior leadership roles at companies including Microsoft and Samsung. His current role is Managing Director of Google’s Android Global Business. French has forged high-impact partnerships across the mobile technology ecosystem. His experience spans sales and business development by bringing new technology to market, most recently Android AI capabilities, giving him unique insights on building products services at scale and delivering customer-led solutions across billions of consumers. Hurt is ranked as one of the top ten most influential cancer/oncology voices on LinkedIn worldwide. She is Chief Patient Officer at Parexel, a leading global clinical development partner. Hurt leads efforts to integrate patient perspectives into drug development and healthcare solutions at their earliest stages. Hurt has more than two decades of leadership experience in the pharmaceutical space. She has worked for GlaxoSmithKline, Transdermal Therapeutics and Colon Cancer Coalition across sales, training and development and has over a decade of experience in patient advocacy. Steve Sanghera said: “I am delighted to announce the appointment of two exceptional Non-Executive Advisers to the Inventus Board. “Jon French, from Google, brings world-class technology leadership and will help guide our continued evolution as a technology first business. “Alongside Jon, Stacy Hurt, Chief Patient Officer at Parexel, brings outstanding patient advocacy experience and joins us to strengthen and challenge our thinking around patient centricity ensuring that everything we do continues to reduce patient burden and improve the clinical trial experience. “These appointments reflect the growth of Inventus within the industry. They also demonstrate our commitment to building a business that combines technological excellence with a genuine focus on the patient.” Hurt added: “To have a patient as a Non-Executive Adviser on the Inventus Board is a huge victory for the patient community and sends a clear signal to the industry about the importance of the patient voice. “I want my role to blaze a trail for patients. Steve’s decision speaks volumes about his ethos, his empathy towards the patient and how much he values that patient lived experience perspective.” French said: “I am very excited to bring my experience from the technology and telecoms industry to focus on life sciences. I’m looking forward to building on what the team has already developed, and my focus will be on implementing AI solutions for the life sciences industry and helping the team build a successful strategy and evolving business." ...Read more

Advancing Precision in Liposomal Nutrient Delivery

Conventional nutrient delivery systems continue to struggle with a fundamental limitation: the body’s digestive environment actively degrades many active compounds before meaningful absorption can occur. Exposure to gastric acid, enzymatic breakdown, oxidation and solubility constraints often results in low systemic availability, forcing formulators to compensate with higher dosages rather than improved delivery. For executives evaluating advanced delivery technologies, the focus has shifted toward systems that not only protect active ingredients but actively reshape how they are absorbed and utilized in vivo. What distinguishes leading liposomal platforms is their ability to replicate biological structures rather than merely encapsulate compounds. Liposomes, composed of phospholipid bilayers similar to human cell membranes, introduce a mechanism that aligns with natural cellular processes. This structural compatibility enables nutrients to bypass passive diffusion limits and instead enter cells through fusion or vesicular uptake, fundamentally altering absorption pathways. The result is not just incremental improvement but a shift toward multi-route absorption, where delivery becomes both protected and actively facilitated. Performance gains in this space are increasingly defined by measurable pharmacokinetic outcomes rather than theoretical advantages. Higher peak plasma concentrations, extended circulation times and increased overall exposure indicate that effective delivery is no longer about survival through digestion alone, but about sustained bioactivity within the body. Technologies that consistently demonstrate improvements in parameters such as Cmax and AUC signal a level of control over nutrient behavior that traditional formats cannot achieve. These outcomes matter because they translate directly into efficacy, dosing efficiency and product differentiation in competitive nutraceutical markets. “The result is not just incremental improvement but a shift toward multi-route absorption, where delivery becomes both protected and actively facilitated.” Consistency at scale remains a critical consideration. Liposomal systems that perform well in controlled environments often face challenges when translated into commercial production. Uniform particle size, stable encapsulation and reproducibility across batches determine whether a technology can move from concept to reliable manufacturing input. Platforms that integrate analytical validation methods such as electron microscopy, encapsulation efficiency testing and pharmacokinetic profiling into their development cycle tend to offer greater confidence to manufacturers. This integration ensures that formulation decisions are continuously refined based on observed in vivo performance rather than isolated laboratory metrics. “Backed by a structured evaluation system that links formulation parameters to in vivo outcomes, it positions itself as a scientifically grounded option for organizations aiming to translate liposomal delivery into reliable commercial products.” Equally important is formulation adaptability. Nutraceutical manufacturers require delivery systems that integrate into diverse dosage forms without compromising stability or dispersibility. Liposomal technologies that enable uniform dispersion in aqueous environments and maintain chemical stability under varying conditions provide a practical advantage, particularly for ingredients that are traditionally difficult to formulate. The ability to preserve active compounds while ensuring compatibility with powders, capsules or functional formats becomes a decisive factor in large-scale product development. EffePharm presents a compelling case within this landscape through its LipoAvail platform, which reflects a tightly integrated approach to design, validation and manufacturing. Its liposomes are engineered below 100 nanometers with controlled morphology and high encapsulation efficiency, enabling consistent delivery performance across multiple active compounds. Clinical and preclinical studies indicate significant improvements in bioavailability, supported by higher peak concentrations and sustained absorption profiles. The platform’s compatibility across dosage forms and its ability to enhance dispersibility and stability address practical formulation constraints faced by manufacturers. Backed by a structured evaluation system that links formulation parameters to in vivo outcomes, it positions itself as a scientifically grounded option for organizations aiming to translate liposomal delivery into reliable commercial products. ...Read more

Competition Among Startup Support Providers Goes Beyond Laboratory Expertise

Competition within biotechnology research and startup development services is becoming less dependent on scientific capability alone. More and more providers are attempting to distinguish themselves by the breadth of support they offer around startup formation, creating a market where buyers compare development models as closely as laboratory credentials. This scenario shows changing expectations from biotechnology founders. Scientific research remains the starting point for startups. But many of them also require support as they establish business structures, prepare development plans or coordinate external advisers. Buyers increasingly evaluate whether a provider understands those wider requirements without losing focus on research quality. That shift creates new competitive pressures. Service providers must decide how far to expand beyond laboratory work. Some remain concentrated on scientific execution, preferring to collaborate with outside specialists when commercial questions arise. Others tend to broaden their involvement by supporting additional aspects of startup development. Neither direction is without tradeoffs. Expanding service offerings may improve continuity for clients, but it also requires additional expertise and closer project coordination. Remaining highly specialized can preserve scientific depth while leaving founders responsible for managing more external relationships. The market may become more segmented as a result. Some biotechnology startups are likely to favor narrowly focused scientific support because they already have experienced leadership teams. Others may place greater value on providers capable of supporting both research progress and company development through connected services. eCompetition also extends to relationship building. Early-stage companies frequently work under monetary constraints that call for careful prioritization of outside spending. Providers need to demonstrate where their involvement contributes to substantial progress instead of encouraging unnecessary project expansion. Another point of consideration is the continuity factor. Biotechnology research typically spans multiple development phases. This makes long-term working relationships attractive as they reduce repeated onboarding or knowledge transfer. Buyers may view the same continuity differently depending on their internal capabilities, creating varied expectations across the market. Founders also face the practical question of preserving oversight. Working with several specialized providers can increase technical depth while demanding greater coordination. Relying on fewer partners may simplify management, but it concentrates more responsibility within a smaller group of external organizations. This is why development services increasingly compete on how they address that balance rather than through scientific claims alone. None of this changes the reality that biotechnology startups depend on credible research before any commercial ambitions become fruitful. Scientific quality remains the foundation of the sector. The competitive difference increasingly lies in how providers support founders once laboratory work begins to interact with company development decisions. The market for biotechnology research and startup development services is unlikely to settle around a single preferred model. Different startups will continue selecting partners according to scientific focus, available resources and internal experience. That variation may become one of the defining characteristics of the sector rather than a temporary stage of its development. ...Read more

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Transdermal Delivery in the Age of Biologics: Charting the Future of Drug Absorption

Pharmaceutical innovation is shifting towards patient-centric transdermal drug delivery systems, which enhance comfort and effectiveness while bypassing gastrointestinal limitations, thereby promising improved adherence and therapeutic.