Recent studies have shown that changes in the levels of NAD+ and its related metabolites (NADome) can indicate the performance of the metabolic function. The challenge, however, lies in measuring the level of NADs as they are difficult to extract from biological fluids, preventing accurate quantitation. NADMED has overcome this challenge by accurately measuring all four forms of NAD directly from blood using an innovative non-destructive extraction methodology.
“The technology was invented during an effort to meet the requirements of research on mitochondrial disorders. It became a need when we wanted to monitor the effect of the vitamin B3 supplement on patients´ NAD levels,” says Jana Buzkova, Chief Operating Officer at NADMED.
Liliya Euro, the Chief Scientist at the company, took the challenge at the University of Helsinki and started developing the technology, which was meant mainly for cells or tissues of mice. Eventually, she was able to extract NAD from human blood and tissue.
Leveraging its groundbreaking technology, NADMED provides a tool for clinical trials and research by pharma companies, offering more profound insights into metabolism. The company helps the research community tap into the NAD knowledge at different levels.
NADMED Ltd.: Setting the Standard in NAD Profiling
NADMED currently provides two types of NAD measurement kits in two different variants. It offers Q-NADMED Blood Kit, a quantitative assay kit for NAD+ and NADH in blood. It is an CE marked in-vitro diagnostic medical device applicable in clinical laboratories that measures concentrations of NAD+ and NADH metabolites in human blood. The company also offers another kit (Q-NAD tissue/cells Kit) to measure these metabolites through tissue or cells. For measuring NADP+ and NADPH, NADMED provides Q-NADP Blood Kit, which also comes in another variant for measurement through tissue or cells.
NADMED sets the standard in this field by getting an accurate measurement in the first attempt. It also offers laboratory services to support research and drug development.
The technology was invented during an effort to meet the requirements of research on mitochondrial disorders. It became a need when we wanted to monitor the effect of the vitamin B3 supplement on patients´ NAD levels
Going from strength to strength, NADMED plans to provide glutathione kits as well and is currently involved in developing the kits for the market. The service provides a comprehensive measurement of six analytes from a single sample.