Bruce Halpryn, CEOAlthough many pharmaceutical companies have successfully developed classic chemotherapeutic agents for cancer treatment, they are plagued with side effects due to the drug conjugate's toxicity. Eikonoklastes Therapeutics has developed a unique immune conjugate technology that targets tissue factors to treat solid tumors and other pathologic conditions. With it, Eikonoklastes Therapeutics expects to provide potency and selectivity with minimal side effects.
Eikonoklastes Therapeutic’s immunoconjugate technology was discovered by its scientific founder, Dr. Zhiwei Hu, who had licensed it from the Ohio State University. He had realized the ubiquitous nature of tissue factor while working at Yale many years earlier. In his research, he identified tissue factor as a common biomarker and therapeutic target on various cancer cells and various types of solid tumors.
Currently, we are focusing on the treatment of triple-negative breast cancer, ovarian cancer, and malignant melanoma, mainly because of its lowest survival rates
Currently, Eikonoklastes Therapeutics is in the preclinical stage, and they are ramping up their efforts to start a clinical trial. Meanwhile, the company verifies its compound’s efficacy on other solid tumors, including melanoma and ovarian cancer. Eikonoklastes Therapeutics is led by visionary leaders who bring a sustained record of successful drug development in multibillion-dollar pharmaceutical companies and early-stage biotech ventures. Both Dato and Harplyn gained extensive experience in drug development while working at P&G Pharmaceuticals. Moreover, Harplyn was also the former director of new drug development at P&G Pharmaceuticals. Sam Lee, the company’s chief business officer, plays a pivotal role in guiding the company steadily down the path to future growth. With their combined leadership and technological prowess, Eikonoklastes Therapeutics is well on its way to revolutionize cancer treatment.
Eikonoklastes Announces Formation of Scientific Advisory Board – Gene Therapy
Wednesday, May 17, 2023
CINCINNATI: Eikonoklastes Therapeutics, a biopharmaceutical company developing a novel gene therapy platform to discover and develop critical treatments for Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative diseases, today announced the formation of a Scientific Advisory Board (SAB) - Gene Therapy, comprised of key leaders in neurology and gene therapy development. The SAB – Gene Therapy will work cohesively with management to advance the company’s gene therapy pipeline. Eikonoklastes’s gene therapy platform is built upon the pioneering work from the lab of Dr. Brian Head, Professor of Anesthesiology at University of California, San Diego.
“I am very pleased to join Eikonoklastes’ Scientific Advisory Board,” said Dame Pamela Shaw, DBE, MD. “I look forward to working with this distinguished group of industry experts to advise the Eikonoklastes team through the development of its innovative technology to address enormous unmet clinical needs.”
“We are fortunate to have the support of a truly world-class group of scientific and industry thought leaders on our Scientific Advisory Board, who will offer their expertise to ensure we optimally design our development program to meet the needs of patients and rapidly advance this technology through regulatory approval to treat patients with this devastating disease,” said Bruce Halpryn, Ph.D., Board Chair and CEO of Eikonoklastes.
“Each member brings unique experience in technology, manufacturing, regulatory affairs, and clinical development. This collection of unparalleled expertise will serve us well as we develop our lead candidate, ET-101, initially for ALS and expanding into several other inadequately treated neurodegenerative diseases,” said Samuel Lee, MD, MBA, MPH, President and Chief Business Officer of Eikonoklastes.
The founding members of the Eikonoklastes Scientific Advisory Board – Gene Therapy are:
Brian Head, PhD
Research Career Scientist, VA San Diego Healthcare System
Professor of Anesthesiology, University of California – San Diego
Russell Lonser, MD
Chairman, Department of Neurological Surgery, Ohio State University Wexner Medical Center
Director, Gene Therapy Institute, Ohio State University
Professor of Neuroscience, Ohio State University College of Medicine
Michael O’Beirne
Former Executive Director, Regulatory Strategy at Sarepta Therapeutics
Vaithianathan “Palani” Palaniappan, PhD
Chief Technology Officer, Pioneering Medicines at Flagship Pioneering
Former Head of Global Technical Operations, Sarepta
Former Global Head of Biologics and New Modality Development, Takeda
Seward Rutkove, MD
Chair, Department of Neurology at Beth Israel Deaconess Medical Center
Professor of Neurology, Harvard Medical School
Dame Pamela Shaw, DBE, MD
Founder and Director, Sheffield Institute for Translational Neuroscience
Professor of Neurology, University of Sheffield
Mark Tuszynski, MD, PhD
Director, UC San Diego Translational Neuroscience Institute
Distinguished Professor of Neuroscience, University of California – San Diego
