ByBug
Redefining Recombinant Protein Generation Through Innovative Biotechnology

In the fast-evolving world of biotechnology, ByBug stands out as a leading research firm on a mission to redefine recombinant protein generation. Through pioneering efforts and groundbreaking technology, they are transcending conventional methodologies, which have long relied on expensive substrates, microorganisms, and large industrial bioreactors. ByBug's revolutionary approach involves utilizing genetically modified black soldier fly eggs and organic waste as substrates through their cutting-edge biotechnology platform, ByBug Synthetics.

"Black soldier flies eat 1,400 times their weight in ten days, making it a better biomass indicator than traditional bioreactors. Also, we use organic waste as a substrate, offering a sustainable and cost-effective production platform for the proteins," explains Gerardo Bluske, Chief Business Officer of ByBug.

Producing recombinant proteins begins with a transcriptomic analysis of black soldier flies feeding on different substrates to identify over-expressing genes. ByBug then performs an analysis to identify specific larval components that need modification to produce the targeted protein, followed by trials with a test protein to increase production within the larvae. The result? Dried larvae rich in protein, healthy fatty acids, vitamin B12, essential minerals, and containing the desired recombinant protein serving as oral vaccines for animals, enzymes, functional ingredients, and even biomaterials.d

One of ByBug's inaugural ventures involved collaboration with AQUIT, a salmon aquaculture company, to develop a specialized oral immunostimulant. By genetically modifying the larvae to optimize quantities of the specific protein, ByBug empowered the client to effortlessly administer the immunostimulant to their salmon population through regular feed, eliminating the need for antibiotics.

In addition to ByBug Synthetics, the company has also developed ByBug Farms, an in-situ modular infrastructure that merges the natural decomposing process of black soldier flies with synthetic biotechnology to enable the efficient conversion of organic waste into recombinant proteins, surpassing industry standards in terms of cost and quality.

"Our key asset is insect eggs. We breed genetically modified black soldier flies and provide clients with the eggs to process organic waste," says Bluske. "Clients worldwide approach us with their recombinant protein requirements, and we develop genetically modified eggs containing the desired protein. These eggs can be used in insect breeding facilities to process organic waste and generate recombinant proteins, or we can provide our clients with our ByBug Farms to process their organic waste and generate their own recombinant proteins."

ByBug's innovation extends beyond the biotech realm. It also addresses the detrimental effects of organic waste disposal in landfills, which contributes to methane emissions and imposes significant costs on companies for waste transportation. ByBug Farms offer a solution, as it allows on-site waste management, enabling the production of economically viable and environmentally sustainable fertilizers, insect meals, and even recombinant proteins. This opens up new income streams for companies while promoting a greener approach to waste management.

Recognized for its revolutionary technology, ByBug has received multiple awards in Argentina, Chile, and the USA. Spearheaded by a team of first-class engineers and entrepreneurs, the company aspires to take its innovative offerings global, internationalizing the technology and focusing on research and development, as well as intellectual property strategies. Their dedication extends to the development of new products with applications across diverse industries.

ByBug's innovative approach to valorizing organic waste, coupled with exceptional technological expertise, yields cost-effective, high-quality byproducts suitable for different industries. This positioning has earned ByBug the status of a trusted and trailblazing leader in the realm of recombinant protein generation. As ByBug continues to push the boundaries of biotechnology, the future looks promising for this visionary firm, poised to revolutionize not only recombinant protein generation but also organic waste management on a global scale.