Navigo Proteins and Eleva Announce Successful Development of an Affinity Chromatography Resin

The resin provides a dependable, flexible, and repeatable Factor H downstream process, overcoming traditional purification methods’ inherent challenges.

B3C newswire Eleva GmbH (Eleva), a manufacturer of superior biologics derived from its patented moss expression system, and Navigo Proteins GmbH (Navigo), a premier protein engineering company and creator of affinity ligands for custom chromatography solutions, announced the successful incorporation of a tailored affinity chromatography resin into the purification process of Eleva’s Complement- Factor. The affinity chromatography resin has been developed using Navigo’s proprietary platform to efficiently purify enzymatically active Factor H from moss cell culture medium.

“We are delighted to be able to work together with a great Eleva team to successfully develop an innovative affinity chromatography solution for the purification of CPV-101. Our custom affinity chromatography technology immediately showed its full potential for efficient production of CPV-101 with excellent purity and yield.

 We are looking forward to continue our support of Eleva by delivering validated resin for production of clinical grade material,” said Florian Settele, Navigos Head of Precision Capturing.

The resin provides a dependable, flexible, and repeatable Factor H downstream process, overcoming traditional purification methods’ inherent challenges. The validation of clinical and industrial resin supply to enable the potential production of CPV-101 is still underway.

Sören Boller, Elevas Head of Downstream Process Development, added, “After receiving the affinity chromatography resin for the purification of CPV-101 from Navigo, we performed numerous experiments to challenge the resin. We were amazed to see an excellent purity after only a single purification step. This powerful tool allows for flexible design of a CPV-101 purification strategy, eventually leading to a successful purification of CPV-101. We are looking forward to continuing the successful collaboration with Navigo and are excited to test the affinity resin in larger scale.”