OCTOBER 2022LIFE SCIENCES REVIEW8IN MY OPINIONver the last decade, immunotherapy has emerged as an exciting option of care for multiple diseases, including cancers, giving hope to millions of patients. Immunotherapeutic approaches harness a patient's own immune system to selectively target cells, often resulting in a different side-effect profile than traditional treatment options.Immunotherapy has two main ways of working, either guiding the body to kill cells or to stop their reproduction, and thus they die. The field has grown tremendously over recent years, with innovations such as cancer vaccinations, chimeric antigen receptor (CAR) T-cell therapy, and immune checkpoint inhibitors, all providing new hope for people with cancers that were previously deemed untreatable. However, despite the undoubted potential, these are still new treatment approaches, and patient response rates continue to vary, with questions and challenges remaining regarding efficacy, targeting, and toxicity. While there are obviously still challenges ahead, the pace at which basic discoveries are being translated into practical clinical therapies to improve patients' lives has never been as compelling as it is now.Personalised medicine can help make immunotherapy a first-line treatment optionBased on the existing total body of evidence, presently, immunotherapies are often offered only as a second or third line of treatment. However, the development of more advanced diagnostics and decision algorithms means personalised approaches to medicine, and the increased understanding of the immune system and biomarkers open the possibility to identify which patients are more likely to respond to immunotherapy rather than traditional treatments. In the future, it might even be possible to determine which patients could benefit from immunotherapy as a form of preventative medicine. As with all treatments, immunotherapy isn't right for everyone. It is vital that the scientific community continues to invest in understanding how individuals will respond to different therapies. This is where some of the challenges lie ­ though scientists have a better understanding than ever before of how the human immune system works, we are still on a steep learning curve regarding the technology to administer personalised treatments. Through a better understanding of how the human body will react to innovative treatments, we can ensure that the patient is truly put at the heart of their care and of treatment development. By Danie du Plessis, Executive VP Medical Affairs, Kyowa KirinIMMUNOTHERAPY: SHAPING A NEW ERA OF PATIENT CENTRIC CAREODanie du Plessis
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