NOVEMBER 2022LIFE SCIENCES REVIEW9go-no go decision points, iterations, critical path, good-to-haves, timelines, budgets, etc.Perhaps the most difficult part is the conception or ideation stage as it requires, in order to be successful, a significant investment in brain power and intellectual input from the entire value chain (pre- and clinical). It is a time-consuming exercise where those involved gather information from scientific literature, public or proprietary databases (OMICS, tissue atlas, patents, clinical trials, etc.) and tap into internal and external expertise. With the available data in hand, the group evaluates central aspects of the target at issue. First and foremost, the biology rationale and the technical feasibility, with the goal of ensuring to the best of the team's knowledge, that there is enough, convincing evidence of a biological mode of action which can be approached, altered or modulated with a pharmacological entity. If there are sufficient "reasons to believe", the target will then move forward into the experimental validation and assay development stages. At this early point is where and when the team struggles between innovation (novel, unvalidated targets)and repetition (programs already attempted by others therefore with certain level of validation). Both options present themselves with the problem of defining and allocating time and resources. Innovation takes time -lots of it-, and continuous investment. Repetition on the other hand, relies in a good part on previous failures, acquired knowledge and experiences and a higher level of confidence in advancement. Both approaches are risky and suffer from high attrition rates. New programs fall often and hard, in most cases before they are official or fully powered. While that's perfectly appropriate -it's best to kill a project early and well, with good decision making and supportive data, before it becomes too expensive, burdensome, unviable-, it adds to the challenges of moving an idea forward beyond the concept level. Thus, the question still stands: What's the better path to progress an idea, a pharmacological target or a proposal for a project? Innovate and generate your own science (risky, high probability of failure, long term investment) or tap into what the scientific community has already a basic knowledge on? As I hope we have established, there's not a fool-proof path to success but the answer might be both. By populating the early discovery pipeline with a variety of new programs including, high risk-high reward, low risk-steady progression, innovative approaches and well validated ones, and something in between, R&D institutions stay competitive and enhance their chances to reach scientific PoC and ultimately the clinic. Ideally, this variety approach will provide a substratum of ideas and targets to resource from, with the potential to die early or to move forward into subsequent stages of the drug discovery process. the most difficult part is the conception or ideation stage as it requires, in order to be successful, a significant investment in brain power and intellectual input from the entire value chain
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